Rfu1: Stimulus for the Ubiquitin Economy

An Inhibitor of a Deubiquitinating Enzyme Regulates Ubiquitin Homeostasis

The dynamic and reversible process of ubiquitin modification controls various cellular activities. Ubiquitin exists as monomers, unanchored chains, or protein-conjugated forms, but the regulation of these interconversions remains largely unknown. Here, we identified a protein designated Rfu1 (regulator of free ubiquitin chains 1), which regulates intracellular concentrations of monomeric ubiqui...

An Inquiry Model for Explanation of Seeking Honor and Self-Esteem in the Foreign Policy of the Islamic Revolution (1980-1998)

With the emergence of the Islamic Revolution in Iran, it is questionable whether a theoretical framework can provide for the components of foreign policy called the Islamic Revolution's self-esteem. Those who believe in "Dignifying Foreign Policy" find that in the foreign policy of the Islamic Revolution, the "Motive of Dignity" has a special place and position, so that during the eight-year wa...

An Analysis of Nigerian Recession

Over the years, Nigeria depends on crude oil proceeds as the major source of national income, foreign exchange and external reserves. This dependence coupled with the huge cost of running and maintaining the political structure among other factors prove disastrous by leading the economy to the worst recession in decades. We therefore, chronicle the origin, effects and way out of the recession v...

Intersection of the multivesicular body pathway and lipid homeostasis in RNA replication by a positive-strand RNA virus.

Like many positive-strand RNA viruses, brome mosaic virus (BMV) RNA replication occurs in membrane-invaginated vesicular compartments. BMV RNA replication compartments show parallels with membrane-enveloped, budding retrovirus virions, whose release depends on the cellular multivesicular body (MVB) sorting pathway. BMV RNA replication compartments are not released from their parent membranes, b...

Editorial: Ubiquitin and Ubiquitin-Relative SUMO in DNA Damage Response